The current healthcare environment is encumbered by regulatory issues and IT systems operating as data collection tools. Physicians must look for ways to unlock the value of the systems they use and lead the charge to change through initiatives aimed at improving outcomes. Over the last ten years the focus has been on the adoption of systems and the collection of data; now is the time to put that data to work by optimizing systems to fulfil their potential. This symposium provides physician leaders with the tools to drive their organizations to the next phase of health technology and medical informatics. Topics include current and future regulatory issues, the increasing need to protect data, interoperability, emerging sources of data, patient engagement, personalized medicine, and an expert look into the future of healthcare.