With shifts in economic incentives, quality metrics, and drivers of performance, population health management has become a critical competency for healthcare organizations. It is clear that healthcare IT must be central to the population health management strategy. Incorporating specific core requirements into the IT framework is necessary for success. This requires interoperability not only within an organization but also between healthcare enterprises. As patients access care across multiple enterprises and disparate technologies, it becomes increasingly challenging to aggregate data, perform real-time analytics, and proactively intervene.